May 15, 2020
Guest Name and Bio:
Dr. Charles Brenner
Dr. Charles Brenner is the Roy J. Carver Chair and Head of
Biochemistry at the University of Iowa, as well as a founding
co-director of the University of Iowa Obesity Initiative. In 2004,
Brenner, then a faculty member at Dartmouth College, discovered
nicotinamide riboside (NR) to be a vital precursor of nicotinamide
adenine dinucleotide (NAD+), which is made available by
nicotinamide riboside kinases (Nrks) that are conserved between
yeast and humans. In 2007, Dr. Brenner’s lab discovered a second
pathway by which NR is converted to NAD+ and showed that NR can
extend the lifespan of yeast cells by virtue of elevating NAD+
levels and increasing the activity of the NAD+-dependent Sir2
enzyme.
In the past decade, Dr. Brenner has made multiple seminal
contributions to NAD+ metabolism, which include engineering a yeast
strain to convert inexpensive NAD+ precursor vitamins into NR,
solving the crystal structure of human Nrk1, developing the methods
for quantitative NAD+ metabolomics, and demonstrating the activity
of oral NR in animal models of fatty liver disease; obesity; type 2
diabetes; diabetic and chemotherapeutic neuropathy; heart failure;
and central brain injury. Dr. Brenner also led the first clinical
trial of NR, which established safe oral availability in humans. He
is currently focusing on the maternal and neonatal effects of oral
NR and translating animal discoveries into evidence-based safe,
human clinical practice for human conditions of metabolic
stress.
What you will learn from this episode:
1) What is the difference between NR (nicotinamide ribosise) and
NAD+ (nicotinamide adenine dinucleotide)
2) What role does NAD+ have in aging and metabolic dysfunction
3) How could NAD+ potentially help in the setting of COVID-19
(Coronavirus)
4) What is the best way to increase your levels of NAD+
5) How can NAD+ help with fatty liver and obesity
How to learn more about our guest:
Twitter: CharlesMBrenner
https://brenner.lab.uiowa.edu/
https://twitter.com/charlesmbrenner
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